{"id":544,"date":"2009-04-14T00:00:00","date_gmt":"2009-04-14T00:00:00","guid":{"rendered":"http:\/\/www.innovationanthology.com\/import\/2018\/02\/01\/innovation-anthology-216\/"},"modified":"2018-02-25T21:30:03","modified_gmt":"2018-02-25T21:30:03","slug":"innovation-anthology-216","status":"publish","type":"post","link":"http:\/\/www.innovationanthology.com\/import\/2009\/04\/14\/innovation-anthology-216\/","title":{"rendered":"Innovation Anthology #216:"},"content":{"rendered":"<p><a href=\"http:\/\/innovationanthology.com\/uploads\/Innovation Anthology 216.mp3\">Download MP3 Link<\/a><\/p>\n<p>\nAnother step forward in understanding what causes prion diseases like mad cow is the recent discovery of the shadoo protein.\n<\/p>\n<p>\nAccording to Dr. David Westaway of the Centre for Prions and Protein Folding Diseases at the University of Alberta, its existence was confirmed by a student in Westaway\u2019s lab.  He showed that shadoo is abundant in the brain and has a lot of features similar to normal prion proteins.\n<\/p>\n<p><b><br \/>\nDR. DAVID WESTAWAY: <\/b><em>We think that they  may be part of a family of a molecules on the surface of brain cells that help brain cells deal with damage.  We have looked at what happens to the shadoo protein in an animal that has a prion disease and we were very surprised to get a very simple answer, that the shadoo protein starts to disappear  In one sense the fact that the shadoo protein disappears when  animals   are replicating prions, it sort of is what we call a tracer.  We didn\u2019t expect to make this discovery, but somehow when the protein is disappearing, it\u2019s telling you that prions are replicating.  <\/em>\n<\/p>\n<p>\nDr. Westaway speculates this may be related to yet another class of proteins called proteazes which function as a waste disposal team.\n<\/p>\n<p><em><br \/>\nThanks today to the <b>Canadian Institutes for Health Research.<\/em>\n<\/p>\n<p>\nFOR INNOVATION ANTHOLOGY,<br \/>\nI&#8217;M CHERYL CROUCHER <\/b>\n<\/p>\n<h2>Guest<\/h2>\n<h3> , <\/h3>\n<h4>, , , , <\/h4>\n<h2>Sponsor<\/h2>\n<h3><a href=\"http:\/\/www.cihr-irsc.gc.ca\">Canadian Institutes of Health Research<\/a><\/h3>\n<p><img decoding=\"async\" src=\"http:\/\/innovationanthology.com\/uploads\/cihr.jpg\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Program Date:<\/strong>\u00a02009-04-14<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Another step forward in understanding what causes prion diseases like mad cow is the recent discovery of the<b> shadoo protein.<\/b>  According to <b>Dr. David Westaway<\/b> of the <b>Centre for Prions and Protein Folding Diseases<\/b> at the University of Alberta,  the shadoo protein is abundant in the brain and has a lot of features similar to normal prion proteins. <em> (Canadian Institutes for Health Research)<\/em><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,62,2,26],"tags":[],"class_list":["post-544","post","type-post","status-publish","format-standard","hentry","category-agriculture","category-canadian-institutes-of-health-research","category-health-and-medicine","category-prions","has-post-title","has-post-date","has-post-category","has-post-tag","has-post-comment","has-post-author",""],"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.innovationanthology.com\/import\/wp-json\/wp\/v2\/posts\/544","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.innovationanthology.com\/import\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.innovationanthology.com\/import\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.innovationanthology.com\/import\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.innovationanthology.com\/import\/wp-json\/wp\/v2\/comments?post=544"}],"version-history":[{"count":3,"href":"http:\/\/www.innovationanthology.com\/import\/wp-json\/wp\/v2\/posts\/544\/revisions"}],"predecessor-version":[{"id":4534,"href":"http:\/\/www.innovationanthology.com\/import\/wp-json\/wp\/v2\/posts\/544\/revisions\/4534"}],"wp:attachment":[{"href":"http:\/\/www.innovationanthology.com\/import\/wp-json\/wp\/v2\/media?parent=544"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.innovationanthology.com\/import\/wp-json\/wp\/v2\/categories?post=544"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.innovationanthology.com\/import\/wp-json\/wp\/v2\/tags?post=544"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}